Amino-Tri-(carboxyethoxymethyl)-methane is acleavablePEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

337.32

Solid

C₁₃H₂₃NO₉

174362-95-9

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)