DBCO-(PEG2-Val-Cit-PAB)2

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

DBCO-(PEG2-Val-Cit-PAB)2 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。DBCO-(PEG2-Val-Cit-PAB)2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

DBCO-(PEG2-Val-Cit-PAB)2 is a dualcleavableADC linkerforantibody-drug conjugates (ADCs). DBCO-(PEG2-Val-Cit-PAB)2 is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs.

IC₅₀& Target

Cleavable

Protease Cleavable

Alkyl/ether

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

1347.56

Formula

C₆₉H₉₄N₁₂O₁₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.