(±)-2-Propyl-4-pentenoic acid (4-en-VPA) 是丙戊酸的主要毒性代谢物。
| Cas No. | 1575-72-0 |
| 别名 | 2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA |
| 化学名 | 2-propyl-4-pentenoic acid |
| Canonical SMILES | C=CCC(C(O)=O)CCC |
| 分子式 | C8H14O2 |
| 分子量 | 142.2 |
| 溶解度 | Slightly soluble in methanol |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid.[1] It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos.[2] Reference:
[1]. Tang, W., and Abbott, F.S. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its α-fluorinated analogue: Phase II metabolism and pharmacokinetics. Drug Metab. Dispos. 25(2), 219-227 (1997).
[2]. Gofflot, F., Nassogne, M.C., Etzion, T., et al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol. Teratol. 17(4), 425-435 (1995). |
