m-PEG6-Amine

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m-PEG6-Amine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

184357-46-8

m-PEG6-Amine 是一种PROTAC 连接桥，属于 PEG 类。m-PEG6-Amine 可用于合成一系列 PROTAC 分子。m-PEG6-Amine 是一种可降解 (cleavable) 的ADC连接桥，用于抗体药物结合物 (ADCs) 的合成。

生物活性

m-PEG6-Amine is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. m-PEG6-Amine is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target^[1]^[2]

Cleavable

PEGs

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

295.37

性状

Liquid

Formula

C₁₃H₂₉NO₆

CAS 号

184357-46-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)