Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. Propargyl-PEG6-NHS ester is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

445.46

C₂₀H₃₁NO₁₀

2093153-99-0

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Please store the product under the recommended conditions in the Certificate of Analysis.