DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. DBCO-NHCO-PEG4-NHS ester is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

649.69

C₃₄H₃₉N₃O₁₀

2100306-58-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.