Propargyl-PEG8-bromide

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2055046-25-6

Propargyl-PEG8-bromide 是一种PROTAC连接桥，属于 PEG 类。Propargyl-PEG8-bromide 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-bromide 是一种不可降解 (non-cleavable) 的ADC连接桥，用于抗体药物结合物 (ADCs) 的合成。

生物活性

Propargyl-PEG8-bromide is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs. Propargyl-PEG8-bromide is anon-cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target^[1]

Non-cleavable

PEGs

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

471.38

Formula

C₁₉H₃₅BrO₈

CAS 号

2055046-25-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.