| CAS NO: | 1626359-59-8 |
| 生物活性 | sulfo-SPDB-DM4 is adrug-linker conjugate for ADCby using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker. | |||||||||
| IC50& Target |
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| 体外研究 (In Vitro) | DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. | |||||||||
| 分子量 | 1075.66 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C46H63ClN4O17S3 | |||||||||
| CAS 号 | 1626359-59-8 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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