Salicyl-AMS是可以抑制分支杆菌生长素生物合成的抑制剂,且在体外缺铁定的条件下能抑制结核分枝杆菌的生长。
| Cas No. | 863238-55-5 |
| Canonical SMILES | O[C@@H]1[C@@H](COS(=O)(NC(C2=C(O)C=CC=C2)=O)=O)O[C@@H](N3C(N=CN=C4N)=C4N=C3)[C@@H]1O |
| 分子式 | C17H18N6O8S |
| 分子量 | 466.43 |
| 溶解度 | DMSO : ≥ 90.5 mg/mL (194.03 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit M. tuberculosis growth in vitro under iron-limited conditions. [1]. Lun S, et al. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrob Agents Chemother. 2013 Oct;57(10):5138-40. [2]. Ferreras JA, et al. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol. 2005 Jun;1(1):29-32. |
