AcLysValCit-PABC-DMAE-SW-163D is adrug-linker conjugates for ADCwhich consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker^[1].

SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase^[1].

1817.05

C₈₅H₁₁₃N₁₉O₂₂S₂

2411007-69-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.