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TUG 891
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TUG 891图片
CAS NO:1374516-07-0
包装与价格：
包装价格(元)
10mg询价
50mg询价

TUG 891 是长链游离脂肪酸 (LCFA) 受体 4 (FFA4/GPR120) 的有效选择性激动剂。
Cas No.1374516-07-0
化学名3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid
Canonical SMILESCC1=CC=C(C2=CC=C(F)C=C2COC3=CC=C(CCC(O)=O)C=C3)C=C1
分子式C23H21FO3
分子量364.41
溶解度≥ 72.8 mg/mL in DMSO, ≥ 18.7 mg/mL in EtOH with ultrasonic, ≥ 1.82 mg/mL in Water with ultrasonic and warming
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TUG-891is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].

References:
[1]. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25

 
 
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