CCT369260

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CCT369260

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2647503-57-7

CCT369260 (compound 1) 是具有口服活性的、B 细胞淋巴瘤 6(BCL6)抑制剂，具有抗肿瘤活性，其IC₅₀值为 520 nM。

生物活性

CCT369260 (compound 1) is an orally avtiveB-cell lymphoma 6 (BCL6)inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits anIC₅₀of 520 nM^[1].

IC₅₀& Target

IC50: 520 nM (BCL6)^[1].

体内研究
(In Vivo)

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model^[1].

Animal Model:	OCI-Ly1 DLBCL xenograft model (female SCID mice)^[1].
Dosage:	15 mg/kg.
Administration:	PO, single dose.
Result:	Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.

Animal Model:	Female Balb/C mice^[1].
Dosage:	1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration:	IV and PO
Result:	Demonstrated moderate clearance (CL 20 mL min^–1kg^–1) with mean oral bioavailability of 54%.

分子量

508.99

性状

Solid

Formula

C₂₄H₃₁ClF₂N₆O₂

CAS 号

2647503-57-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 300 mg/mL(589.40 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9647 mL	9.8234 mL	19.6468 mL
5 mM	0.3929 mL	1.9647 mL	3.9294 mL
10 mM	0.1965 mL	0.9823 mL	1.9647 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。