VU 0365114 是一种 mAChR M5 正变构调节剂，EC50 为 2.7 μM。
| Cas No. | 1208222-39-2 |
| 化学名 | 1-([1,1'-biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione |
| Canonical SMILES | FC(F)(OC1=CC=C(C(C2=O)=C1)N(C2=O)CC3=CC=C(C4=CC=CC=C4)C=C3)F |
| 分子式 | C22H14F3NO3 |
| 分子量 | 397.35 |
| 溶解度 | <39.73mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. References:
[1]. Bridges TM, et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22. |
