Apoptotic agent-2

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Apoptotic agent-2

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CAS NO:

2482310-18-7

Apoptotic agent-2 (compound 14b) 通过下调 Bcl-2 和上调 Bax 和 caspase-3 诱导细胞凋亡 (apoptosis)。Apoptotic agent-2 具有抗增殖活性，可用于癌症研究。

生物活性

Apoptotic agent-2 (compound 14b) inducesapoptosisby down-regulation ofBcl-2and up-regulation ofBaxand caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used forcancerresearch^[1].

IC₅₀& Target^[1]

Bax

Caspase 3

Bcl-2

体外研究
(In Vitro)

Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC₅₀values of 1.96, 1.12, 2.38 and 107.5 μM, respectively^[1].
Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds^[1].

Cell Cycle Analysis^[1]

Cell Line:	HepG-2 cells
Concentration:	1.12 μM
Incubation Time:	24 hours
Result:	The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased.

Apoptosis Analysis^[1]

Cell Line:	HepG-2 cells
Concentration:	1.12 μM
Incubation Time:	24 hours
Result:	Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.

分子量

481.96

Formula

C₂₅H₁₆ClN₇S

CAS 号

2482310-18-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.