Bax activator-1

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Bax activator-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1638526-94-9

Bax activator-1 (compound 106) 是一种Bax激活剂，诱导 Bax 依赖性肿瘤细胞凋亡。

生物活性

Baxactivator-1 (compound 106) is aBaxactivator that induces Bax-dependent tumor cellapoptosis^[1].

IC₅₀& Target

Bax

体外研究
(In Vitro)

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion^[1].

Apoptosis Analysis^[1]

Cell Line:	Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells
Concentration:	20 μM, 40 μM , 60 μM , 80 μM
Incubation Time:	48 hours
Result:	Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.

体内研究
(In Vivo)

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice^[1].

Animal Model:	Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)^[1]
Dosage:	40 mg/kg
Administration:	Given i.p., each day for 13 days
Result:	Exhibited anti-tumor activity as a single-agent.

分子量

488.62

Formula

C₂₉H₃₆N₄O₃

CAS 号

1638526-94-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.