PROTAC Bcl-xL degrader-1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PROTAC Bcl-xL degrader-1 是包含Bcl-xL(Bcl-2家族成员) 配体结合基团，linker 和IAPE3 连接酶结合基团的PROTAC。PROTAC Bcl-xL degrader-1 是一种有效的Bcl-xL降解剂，对人血小板和 MyLa 1929 细胞具有毒性，IC₅₀值分别为 62 nM 和 8.5 μM。

生物活性

PROTACBcl-xL degrader-1 is aPROTACthat comprises aBcl-xL(Bcl-2family member) ligand binding group, a linker and anIAPE3 ligasesbinding group.PROTACBcl-xL degrader-1 is a potentBcl-xLdegrader, and shows toxicity for human platelets and MyLa 1929 cells withIC₅₀values of 62 nM and 8.5 μM, respectively^[1].

IC₅₀& Target^[1]

cIAP1

Bcl-xL

体外研究
(In Vitro)

PROTAC Bcl-xL degrader-1 (Compound 8a; 0.01-3 μM; 16 hours; MyLa 1929 cells) treatment potently and dose-dependently induces BCL-XL degradation in MyLa 1929 cells^[1].
PROTAC Bcl-xL degrader-1 (Compound 8a) is able to induce remarkable BCL-XL degradation in a dose-dependent manner across all tested cell lines (A549, MDA-MB-231, SW620, MeWo, SK-MEL28, and CHL-1 cell lines), suggesting the broad application across cancer types^[1].

Western Blot Analysis^[1]

Cell Line:	MyLa 1929 cells
Concentration:	0.01 μM, 0.03 μM, 0.1 μM, 0.3 μM, 1 μM, 3 μM
Incubation Time:	16 hours
Result:	Potently and dose-dependently induced BCL-XL degradation in MyLa 1929 cells.

分子量

1514.28

Formula

C₇₆H₉₆ClF₃N₁₀O₁₁S₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.