JNJ-4355

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JNJ-4355

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2697112-32-4

JNJ-4355 是一种高效的MCL-1(髓细胞白血病 -1) 抑制剂，其K_I为 18 pM。JNJ-4355 具有抗肿瘤活性。

生物活性

JNJ-4355 is a highly potentMCL-1(myeloid cell leukemia-1) inhibitor, withK_Iof 18 pM. JNJ-4355 shows antitumor activity^[1]^[2].

IC₅₀& Target

Mcl-1

18 pM (Ki)

体外研究
(In Vitro)

JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples^[2].

体内研究
(In Vivo)

JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft^[2].

分子量

760.32

Formula

C₄₀H₄₃ClFN₅O₅S

CAS 号

2697112-32-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.