Bcl-2-IN-4 是一种有效的、具有口服活性的选择性 Bcl-2 抑制剂，IC50为 1.5 nM。Bcl-2-IN-4 的选择性比 Bcl-xL 高于 200 倍 (IC50为 411 nM)。Bcl-2-IN-4 抑制 RS4； 11 细胞增殖，IC50为 2.7 nM (WO2021180040A1; compound 2)。
| 生物活性 | Bcl-2-IN-4 is a potent, orally active and selectiveBcl-2 inhibitorwith anIC50of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity overBcl-xL(IC50of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with anIC50of 2.7 nM (WO2021180040A1; compound 2)[1]. |
| IC50& Target[1] | Bcl-2 1.5 nM (IC50) | Bcl-xL 411 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
