Z-VDVAD-FMK

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Z-VDVAD-FMK

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

210344-92-6

Z-VDVAD-FMK 是一种特异性的caspase-2抑制剂。Z-VDVAD-FMK 可减少 Lovastatin 诱导的细胞凋亡 (apoptosis)。

生物活性

Z-VDVAD-FMK is a special inhibitor ofcaspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-inducedapoptosis^[1]^[2]^[3].

IC₅₀& Target^[1]

Caspase-2

体外研究
(In Vitro)

Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death^[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells^[2].
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%^[3].

Cell Viability Assay^[1]

Cell Line:	The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152)
Concentration:	100 μM
Incubation Time:	22 hours
Result:	Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.

分子量

695.73

性状

Solid

Formula

C₃₂H₄₆FN₅O₁₁

CAS 号

210344-92-6

Sequence Shortening

{Cbz}-V{Asp(OMe)}-VA-{Asp(OMe)}-CH2F

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)