Z-LEVD-FMK

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Z-LEVD-FMK

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1135688-25-3

Z-LEVD-FMK 是一种细胞渗透性的caspase-4抑制剂。 Z-LEVD-FMK 阻断 ER 应激诱导的癌细胞凋亡。

生物活性

Z-LEVD-FMK is a cell-permeablecaspase-4inhibitor. Z-LEVD-FMK blocks ER stress-inducedapoptosisincancercells^[1].

IC₅₀& Target^[1]

Caspase-4

体外研究
(In Vitro)

Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells^[1].
Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells^[1].
Z-LEVD-FMK (20 μM, 96 h) completely blocks E₂-induced PARP cleavage in 5C cells^[2].
Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells^[2].

Western Blot Analysis^[1]

Cell Line:	hRPE cells (treated with IL-1β of 2 ng/mL for additional 24 h)
Concentration:	2 ng/mL
Incubation Time:	30 min
Result:	Inhibited IL-1β-induced IL-8 production.

分子量

652.71

Formula

C₃₁H₄₅FN₄O₁₀

CAS 号

1135688-25-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.