Tubulin inhibitor 30

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Tubulin inhibitor 30 (Compound 15) 是一种tubulin组合抑制剂，IC₅₀为 0.52 μM。Tubulin inhibitor 30 可以诱导ferroptosis。

生物活性

Tubulin inhibitor 30 (Compound 15) is atubulinassembly inhibitor with anIC₅₀of 0.52 μM. Tubulin inhibitor 30 can induceferroptosis^[1].

IC₅₀& Target

IC50: 0.52 μM (Tubulin)^[1]

体外研究
(In Vitro)

Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells^[1].
Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes^[1].

Cell Viability Assay^[1]

Cell Line:	MCF-7, U-87 MG and OVCAR-3 cells
Concentration:	0-100 nM
Incubation Time:	48 h
Result:	Inhibited the cell viability with IC₅₀s of 4.0, 10.06 and 2.852 nM against MCF-7, U-87 MG and OVCAR-3 cells, respectively.

Western Blot Analysis^[1]

Cell Line:	U-87 MG and OVCAR-3 cells
Concentration:	0-100 nM
Incubation Time:	48 h
Result:	Induced a significant increase of cleaved PARP.

体内研究
(In Vivo)

Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe²⁺accumulation in mice^[1].

Animal Model:	BALB/C^nu/numice, U-87 MG or SKOV-3 model^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection, every 2 days
Result:	Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe²⁺accumulation.

分子量

405.40

Formula

C₂₂H₁₉N₃O₅

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.