TopoisomeraseI inhibitor 8 is a potenttopoisomeraseIinhibitor.TopoisomeraseI inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells^[1].

Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC₅₀s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively^[1].
Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective thanSN-38(HY-13704), with IC₅₀of compound/IC₅₀of SN-38=0.51^[1].

420.43

C₂₄H₂₁FN₂O₄

210346-40-0

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