CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibitsDNAtopoisomeraseIwith anIC₅₀of 2.3 μM. CH-0793076 is efficacious against cells expressingBCRP(breastcancerresistance protein)^[1].

CH0793076 (TP3076) (6 days at 37℃) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC₅₀s of 0.35 and 0.18 nM, respectively^[1].

TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses), a water-soluble prodrug of CH0793076, shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP (WiDr, HT-29, NCI-H460 and AsPC-1, HCT116, COLO 201, HCT-15, Calu-6 and NCI-N87)^[1].

458.51

C₂₆H₂₆N₄O₄

534605-78-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.