MDM2/4-p53-IN-1

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MDM2/4-p53-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MDM2/4-p53-IN-1 是一种有效的MDM2-p53和MDM4-p53抑制剂，对 MDM2-p53 和 MDM4-p53 的IC₅₀值分别为 35.9、57.4 nM。MDM2/4-p53-IN-1 显示出抗增殖活性。

生物活性

MDM2/4-p53-IN-1 is a potentMDM2-p53andMDM4-p53inhibitor withIC₅₀values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity^[1].

IC₅₀& Target

IC₅₀: 35.9 nM (MDM2-p53); 57.4 nM (MDM4-p53)^[1]

体外研究
(In Vitro)

MDM2/4-p53-IN-1 (compound 3f) (0-100 μM; 48-96 h) shows antiproliferative activity with IC₅₀values of 20.9, 14.7, 11.5, 12.4 μM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively^[1].

Cell Proliferation Assay^[1]

Cell Line:	HCT116, SJSA-1, LNCaP, MCF-7 cells
Concentration:	0-100 μM
Incubation Time:	48 h (HCT116), 72 h (MCF7), 96 h (SJSA-1, LNCaP)
Result:	Showed antiproliferative activity with IC₅₀values of 20.9, 14.7, 11.5, 12.4 μM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively.

分子量

609.46

Formula

C₃₂H₂₂Cl₂N₆O₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.