Amifostine trihydrate

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CAS NO:

112901-68-5

WR2721 trihydrate

Amifostine trihydrate (WR2721 trihydrate) 是一种广谱细胞保护剂和辐射防护剂。Amifostine trihydrate 可选择性保护正常组织免受放射线和化学疗法造成的损害。Amifostine trihydrate 是有效的HIF-α1和p53诱导剂。Amifostine trihydrate 通过清除氧衍生的自由基来保护细胞免受损伤。Amifostine trihydrate 可降低肾脏毒性并具有抗血管生成作用。

生物活性

Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potenthypoxia-inducible factor-α1 (HIF-α1)andp53inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Amifostine (0.78125-100 μM, 24 h) trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM^[5].

体内研究
(In Vivo)

Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice^[5].

Animal Model:	Male C57BL/6 mice with myocardial I/R injury^[5]
Dosage:	400 mg/kg
Administration:	Intravenous injection; 4 hours
Result:	Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS. Significantly reduced the expression of cleaved caspase 3 and Bax while enhanced the expression of SOD1, SOD2 and Bcl2. Significantly increased SOD activity and reduced MDA levels.

Clinical Trial

分子量

284.27

Formula

C₅H₂₁N₂O₇PS

CAS 号

112901-68-5

中文名称

氨磷汀三水合物；安磷汀三水合物；阿米福汀三水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.