Kdo2-Lipid A ammonium

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CAS NO:

1246298-62-3

Kdo2-Lipid A ammonium 是一种化学定义的脂多糖 (LPS) ，其内毒素活性等同于 LPS。Kdo2-Lipid A ammonium 对TLR4具有高度选择性。Kdo2-Lipid A ammonium 刺激TNF和PGE2的释放。

生物活性

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective forTLR4. Kdo2-Lipid A ammonium stimulates the release of bothTNFandPGE2^[1].

IC₅₀& Target

TLR4

体外研究
(In Vitro)

Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures^[1].

RT-PCR^[1]

Cell Line:	TNF and PGE2
Concentration:	1 μM
Incubation Time:
Result:	Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.

体内研究
(In Vivo)

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats^[1].

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g)^[1]
Dosage:	0.1 to 10 μg
Administration:	I.T.; 0.1-10 μg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 μg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

Clinical Trial

分子量

2306.84

性状

Solid

Formula

C₁₁₀H₂₁₄N₆O₃₉P₂

CAS 号

1246298-62-3

结构分类

Others

来源

E. coli

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)