Theophylline sodium acetate

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CAS NO:

8002-89-9

1,3-Dimethylxanthine sodium acetate
Theo-24 sodium acetate

Theophylline (1,3-Dimethylxanthine) sodium acetate 是有效的磷酸二酯酶 (PDE) 抑制剂，腺苷受体拮抗剂，和组蛋白脱乙酰酶 (HDAC) 活化剂。Theophylline (1,3-Dimethylxanthine) sodium acetate 抑制 PDE3 活性，放松气道平滑肌。Theophylline (1,3-Dimethylxanthine) sodium acetate 通过增加 IL-10 和抑制 NF-κ B进入细胞核而具有抗炎活性。Theophylline (1,3-Dimethylxanthine) sodium acetate 诱发细胞凋亡 (apoptosis)。Theophylline (1,3-Dimethylxanthine) sodium acetate 可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。

生物活性

Theophylline (1,3-Dimethylxanthine) sodium acetate is a potentphosphodiesterase (PDE)inhibitor,adenosine receptorantagonist, andhistone deacetylase (HDAC)activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibitsPDE3activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increaseIL-10and inhibitNF-κBinto the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate inducesapoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research^[1]^[2]^[3]^[4]^[5].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Theophylline (1,3-Dimethylxanthine) sodium acetate (1-1000 μM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries^[1].
Theophylline (1,3-Dimethylxanthine) sodium acetate (10 μg/mL; 24 h; eosinophils) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2^[2].
Theophylline (1,3-Dimethylxanthine) sodium acetate (0-500 μM; 2 h; A549 cells) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner^[3].
Theophylline (1,3-Dimethylxanthine) sodium acetate (0-1000 μM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression^[4].

Western Blot Analysis^[3]

Cell Line:	A549 cells
Concentration:	0, 20, 100 and 500 μM
Incubation Time:	2 hours
Result:	Decreased the expression of NF-κB p65 and I-κBα degradation in a concentration-dependent manner.

Western Blot Analysis^[2]

Cell Line:	Eosinophils
Concentration:	10 μg/mL
Incubation Time:	24 hours
Result:	Decreased the expression of Bcl-2.

体内研究
(In Vivo)

Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO^[1].

Animal Model:	Male Swiss mice^[1]
Dosage:	100 mg/kg
Administration:	Intraperitoneal injection; daily, for 9 days
Result:	Increased IL-6 and IL-10 levels and inhibited TNF-α and NO.

Clinical Trial

分子量

284.18

Formula

C₉H₁₀N₄Na₂O₄

CAS 号

8002-89-9

中文名称

乙酸钠茶碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.