Folinic acid disodium

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CAS NO:

163254-40-8

Leucovorin disodium

Folinic acid (Leucovorin) disodium 是一种生物叶酸，是维生素 B9 的一种形式。Folinic acid disodium 通常与 Methotrexate (MTX) (HY-14519) 作为救援剂一起给药，以降低 MTX 诱导的毒性。Folinic acid disodium 和氟尿嘧啶辅助化疗对结肠癌有效。

生物活性

Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along withMethotrexate (MTX)(HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma^[1]^[2]^[3].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Folinic acid disodium (5, 50 μg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h^[1].

体内研究
(In Vivo)

Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)^[2].

Animal Model:	24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)^[2]
Dosage:	7.0 mg/kg
Administration:	Intraperitoneal injection; every second day; for 3 weeks
Result:	Following MTX administration appears to reverse this growth inhibition.

Clinical Trial

分子量

517.40

Formula

C₂₀H₂₁N₇Na₂O₇

CAS 号

163254-40-8

中文名称

亚叶酸二钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.