ATR-IN-14 (化合物 1) 是一种有效的ATR激酶抑制剂。ATR-IN-14 抑制 ATR 信号通路下游 CHKI 蛋白磷酸化，25 nM 时抑制率为 98.03%。ATR-IN-14 在 LoVo 细胞中表现出良好的抗癌活性，IC50为 64 nM。
| 生物活性 | ATR-IN-14 (compound 1) is a potentATRkinase inhibitor. ATR-IN-14 inhibitsATRsignaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with anIC50of 64 nM[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
