Aurora Kinases-IN-2

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Aurora Kinases-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2241914-86-1

Aurora Kinases-IN-2 (compound 12Aj) 是一种有效的 Aurora 激酶抑制剂 (Aurora kinases)，对 Aurora A 和 Aurora B 的IC₅₀值分别为 90 和 152 nM。Aurora Kinases-IN-2 通过调节细胞周期蛋白 B1 和 cdc2 将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 可用于癌症研究。

生物活性

Aurora Kinases-IN-2 (compound 12Aj) is a potentAurora kinasesinhibitor withIC₅₀values of 90 and 152 nM forAurora AandAurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used forcancerresearch^[1].

IC₅₀& Target^[1]

Aurora A

90 nM (IC₅₀)

Aurora B

152 nM (IC₅₀)

体外研究
(In Vitro)

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC₅₀values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively^[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells^[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2^[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells^[1].

Western Blot Analysis^[1]

Cell Line:	HeLa cells
Concentration:	0, 1, 5 and 10 μM
Incubation Time:	24 hours
Result:	Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.

分子量

435.86

Formula

C₂₂H₁₈ClN₅O₃

CAS 号

2241914-86-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.