CCT129202

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CCT129202

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

942947-93-5

CCT129202 是极光激酶 (aurora) 抑制剂，对极光激酶 A，B，C 的IC₅₀值分别为42，198 和227 nM。

生物活性

CCT129202 is anaurorakinase inhibitor withIC₅₀s of 42, 198, and 227 nM foraurora A, B and C, respectively.

IC₅₀& Target^[1]

Aurora A

42 nM (IC₅₀)

Aurora B

198 nM (IC₅₀)

Aurora C

227 nM (IC₅₀)

体外研究
(In Vitro)

CCT129202 causes the accumulation of human tumor cells with z4N DNA content, leading to apoptosis. CCT129202 is found to induce apoptosis with GI₅₀values that ranges between 0.08 and 1.7 μM. CCT120202-treated human tumor cells shows a delay in mitosis, abrogation of nocodazole-induced mitotic arrest, and spindle defects. CCT129202 Causes p21Up-regulation, Rb Hypophosphorylation, and H2F-DependentTK1Down-regulation^[1].

体内研究
(In Vivo)

Growth of HCT116 xenografts in nude mice is inhibited after i.p. administration of CCT129202. p21, the cyclin-dependent kinase inhibitor, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription^[1].

分子量

497.02

性状

Solid

Formula

C₂₃H₂₅ClN₈OS

CAS 号

942947-93-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 1 mg/mL(2.01 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0120 mL	10.0600 mL	20.1199 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。