Aurora A/PKC-IN-1 (Compound 2e) 是一种有效的Aurora A (AurA)和PKC (α, β1, β2, θ)双效抑制剂，对 AurA 和 PKCα 分别具有 6.9 nM 和 16.9 nM。Aurora A/PKC-IN-1对乳腺癌细胞具有抗增殖和抗转移活性。
| 生物活性 | Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor ofAurora A(AurA)andPKC(α, β1, β2, and θ) kinaseswithIC50s of 6.9 nM and 16.9 nM for AurA andPKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breastcancercells and antimetastatic activity[1]. |
| IC50& Target[1] | Aurora A 6.9 nM (IC50) | PKCα 16.9 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
