Aurora inhibitor 1

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Aurora inhibitor 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2227019-45-4

Aurora inhibitor 1 是一种有效的Aurora抑制剂，抑制Aurora A和Aurora B激酶的IC₅₀分别 ≤4 nM 和 ≤13 nM。

生物活性

Aurora inhibitor 1 is a potentAurorainhibitor with anIC₅₀of ≤ 4 nM and ≤13 nM forAurora AandAurora Bkinase, respectively^[1].

IC₅₀& Target

Aurora A

4 nM (IC₅₀)

Aurora B

13 nM (IC₅₀)

体外研究
(In Vitro)

Aurora inhibitor 1 (Compound 16) exhibits K_dvalues of 0.01 nM for both Aurora A and Aurora B kinase^[1].

体内研究
(In Vivo)

Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally^[1].

分子量

459.57

Formula

C₂₃H₂₅N₉S

CAS 号

2227019-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.