JNJ-6204 是一种CSNK1D和CSNK1E的双重抑制剂 (CSNK1DIC50=2.3 nM; CSNK1EIC50=137 nM)，且具有良好的脑渗透性。
| 生物活性 | JNJ-6204 is a dual inhibitor forCSNK1D(Casein Kinase1 Delta) andCSNK1E(Casein Kinase1 Epsilon) (CSNK1DIC50=2.3 nM; CSNK1EIC50=137 nM). JNJ-6204 shows good brain exposure[1][2]. |
| IC50& Target | |
体外研究
(In Vitro) | JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
