CDK1-IN-4

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CDK1-IN-4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CDK1-IN-4 (10d) 是CDK1的选择性抑制剂，对 CDK1，CDK2 和 CDK5 的IC₅₀值分别为 44.52，624.93 和 135.22 nM。CDK1-IN-4 通过影响细胞周期抑制癌细胞生长。CDK1-IN-4 可用于癌症的研究。

生物活性

CDK1-IN-4 (10d) is a selectiveCDK1inhibitor withIC₅₀s of 44.52, 624.93 and 135.22 nM forCDK1,CDK2andCDK5, respectively. CDK1-IN4 inhibits the growth ofcancercells by affecting cell cycle. CDK1-IN-4 can be used for the research ofcancer^[1].

IC₅₀& Target

CDK1

44.52 nM (IC₅₀)

CDK2

621.93 nM (IC₅₀)

CDK5

135.22 nM (IC₅₀)

体外研究
(In Vitro)

CDK1-IN-4 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells^[1].
CDK1-IN-4 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC₅₀s of 36.8, 305.17 and 369.37 nM, respectively^[1].
CDK1-IN-4 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC₅₀s of 2488, 8957, 7620, 8541, 4294 and 1156 nM, respectively^[1].
CDK1-IN-4 (0.88 μM; 24 h) decreases CDK1 protein level in vitro and affects cell cycle^[1].

Cell Proliferation Assay^[1]

Cell Line:	PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration:	0-10 μM
Incubation Time:	24 hours
Result:	Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cell over 69%, and inhibited MDA-PATC53 and PL45 cells with IC₅₀s of 0.88 and 1.14 μM, respectively.

Western Blot Analysis^[1]

Cell Line:	MDA-PATC53 cell line
Concentration:	0.88 μM
Incubation Time:	24 hours
Result:	Downregulated CDK1 protein level compared to untreated cells.

Cell Cycle Analysis^[1]

Cell Line:	MDA-PATC53 cell line
Concentration:	0.88 μM
Incubation Time:	24 hours
Result:	Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.

分子量

474.02

Formula

C₂₆H₂₄ClN₅S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.