LY3177833 monhydrate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1627696-53-0

LY3177833 (Example 4) monhydrate 是一种具有口服活性的CDC7和pMCM2的抑制剂，其IC₅₀值分别为 3.3 nM 和 290 nM。LY3177833 monhydrate 是一种衰老诱导剂。

生物活性

LY3177833 (Example 4) monhydrate is an orally activeCDC7andpMCM2inhibitor withIC₅₀values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer^[1]^[2].

IC₅₀& Target^[1]

Cdc7

3.3 nM (IC₅₀)

pMCM2

290 nM (IC₅₀)

体外研究
(In Vitro)

LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells^[2].

Western Blot Analysis^[2]

Cell Line:	Hep3B cells
Concentration:	10 μM
Incubation Time:	4 days
Result:	Increased the expression of human SA-β-gal.

体内研究
(In Vivo)

LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation^[1].

Animal Model:	Female athymic Balb/c nude mice (5-6 weeks old) with SW620 cells^[1]
Dosage:	10.4 mg/kg, 20.8 mg/kg and 31.2 mg/kg
Administration:	Oral gavage; twice a day for 2 weeks
Result:	Showed dose dependent antitumor activity in SW620 mouse xenograft tumor model.

分子量

327.31

性状

Solid

Formula

C₁₆H₁₄FN₅O₂

CAS 号

1627696-53-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)