CDK4/6-IN-3 是一种脑渗透性的CDK4/CDK6抑制剂，Ki分别为<0.3 nM 和 2.2 nM。CDK4/6-IN-3 抑制 CDK1，Ki为 110 nM。CDK4/6-IN-3 可用于胶质母细胞瘤的研究。
| 生物活性 | CDK4/6-IN-3 is a brain-penetrantCDK4/CDK6inhibitor withKis of<0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibitsCDK1with a Kiof 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. |
| IC50& Target | CDK4 0.3 nM (Ki) | CDK6 2.2 nM (Ki) | CDK1 110 nM (Ki) |
|
体外研究
(In Vitro) | CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
