RJR-2403 oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) 是一种神经元烟碱受体激动剂，对 α4β2 亚型 (Ki=26 nM) 具有高选择性； >1,000 倍的选择性比 α7 受体（Ki = 3.6 μM）。
| Cas No. | 220662-95-3 |
| 别名 | (3E)-N-甲基-4-(3-吡啶基)-3-丁烯-1-胺草酸盐,(E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate |
| 化学名 | (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine;oxalic acid |
| Canonical SMILES | CNCCC=CC1=CN=CC=C1.C(=O)(C(=O)O)O |
| 分子式 | C12H16N2O4 |
| 分子量 | 252.27 |
| 溶解度 | Soluble to 100 mM in sterile water |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); >1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). References:
[1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
[2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
[3]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8. |
