CDK4/6-IN-7

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CDK4/6-IN-7

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2649120-20-5

CDK4/6-IN-7 是一种有效，选择性和具有口服活性的CDK4/6抑制剂，IC₅₀值分别为 1.58 和 4.09 nM。CDK4/6-IN-7 可用于乳腺癌的研究。

生物活性

CDK4/6-IN-7 is a potent, selective and orally activeCDK4/6inhibitor, withIC₅₀s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breastcancer^[1].

IC₅₀& Target^[1]

CDK4

1.58 nM (IC₅₀)

CDK6

4.09 nM (IC₅₀)

体外研究
(In Vitro)

CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC₅₀of 0.92 μM^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 μM
Incubation Time:	48 hours
Result:	Inhibited MCF-7 cells growth, with an IC₅₀of 0.92 μM.

体内研究
(In Vivo)

CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice^[1].

Animal Model:	Female nude mice (5 weeks) bearing MCF-7 tumor^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage once daily for 7 days
Result:	Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.

分子量

387.82

Formula

C₁₈H₁₈ClN₅O₃

CAS 号

2649120-20-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.