CDK8-IN-6 (compound 9) 是一种有效的细胞周期蛋白依赖性激酶8 (CDK8)抑制剂，Kd为 13 nM。CDK8-IN-6 对 MOLM-13、OCI-AML3、MV4-11、NRK 和 H9c2 细胞具有细胞毒性，IC50s 分别为 11.2、7.5、8.6、20.5、12.5-25 μM。CDK8-IN-6 具有研究 AML 癌症的潜力。
| 生物活性 | CDK8-IN-6 (compound 9) is a potentcyclin-dependent kinase8 (CDK8)inhibitor with anKdof 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 11.2, 7.5, 8.6, 20.5, 12.5-25 μM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
