CDK7-IN-4

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CDK7-IN-4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2326428-25-3

LY3405105

CDK7-IN-4 (compound I) 是一种有效的CDK7(细胞周期蛋白依赖激酶 7) 抑制剂。CDK7-IN-4 显示出抗癌活性。CDK7-IN-4 以剂量依赖性的方式抑制结肠、乳腺、肺、卵巢和胃等多种组织学肿瘤细胞系的体外生长。

生物活性

CDK7-IN-4 (compound I) is a potentCDK7(Cyclin-dependent kinase 7) inhibitor. CDK7-IN-4 shows anticancer activity. CDK7-IN-4 inhibits the in vitro growth ofcancercell lines from a variety of histologies including colon , breast , lung , ovary and stomach , in a dose dependent manner^[1].

IC₅₀& Target

CDK7

体外研究
(In Vitro)

CDK7-IN-4 (compound I) exhibits significant inhibitory activity against NCI-H446, SNU-16, HCC1806, A2780, MCF7, HCT116, and NCI-H460 cells, with IC₅₀values of 0.01419, 0,02312, 0.02553, 0.02651, 0.03201, 0.04601, and 0.0479, respectively^[1].

Clinical Trial

分子量

497.63

Formula

C₂₆H₃₉N₇O₃

CAS 号

2326428-25-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.