CDK2-IN-12

立即咨询

CDK2-IN-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2410402-88-7

CDK2-IN-12 (compound 10b) 是一种有效的CDK2抑制剂，其IC₅₀为 11.6 μM。CDK2-IN-12 抑制hCA亚型 I、II、IX 和 XII，K_I值分别为 3534、638.4、44.3 和 48.8 nM。CDK2-IN-12 具有抗癌活性。

生物活性

CDK2-IN-12 (compound 10b) is a potentCDK2inhibitor, with anIC₅₀of 11.6 μM. CDK2-IN-12 inhibitshCA(carbonic anhydrase) isoforms I, II, IX and XII, withK_Ivalues of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity^[1].

IC₅₀& Target

CDK2

11.6 μM (IC₅₀)

CDK9

>12.5 μM (IC₅₀)

体外研究
(In Vitro)

CDK2-IN-12 (compound 10b) exerts outstanding anti-proliferative activity against leukemia (CCRF-CEM, HL-60TB, K-562 and MOLT-4), non-small cell lung cancer (HOP-92), colon cancer (COLO 205, HCT-116 and SW-620), renal (ACHN) and breast (MDA-MB-468) cell lines with GI% (percentage growth inhibition) ranging from 80 to 100%^[1].
CDK2-IN-12 displays much enhanced growth inhibitory activity, under normoxic and hypoxic conditions, against MDA-MB-468 (IC50 = 1.37 ± 0.07 and 3.03 ± 0.11 μM) than MCF-7 cells (IC50 = 6.80 ± 0.17 and 15.10 ± 0.82 μM)^[1].

分子量

447.47

Formula

C₂₀H₁₇N₉O₂S

CAS 号

2410402-88-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.