NSC693868 是一种选择性的CDK1和CDK5抑制剂，IC50s分别为 600 nM 和 400 nM。NSC693868 对 GSK3β 也有较弱的抑制作用，IC50为 1 μM，且不影响细胞分裂周期因子25 (CDC25) 活性。NSC693868 用于研究 CDK1 和 CDK5 在各种信号通路中的作用。
| 生物活性 | NSC693868 is a selective inhibitor ofCDK1andCDK5withIC50sof 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with anIC50of 1 μM) and does not block CDC25 activity. NSC693868 is used to help define the roles ofCDK1andCDK5in various signaling pathways[1]. |
| IC50& Target | Cdk1/cyclin B 600 nM (IC50) | Cdk5/p25 400 nM (IC50) | GSK-3β 1 μM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
