Carbonic anhydrase inhibitor 14

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CAS NO:

2410402-75-2

Carbonic anhydrase inhibitor 14 (Compound 8b) 是一种碳酸酐酶 (carbonic anhydrase) 抑制剂，其对 hCA I、hCA II、hCA IX 和 hCA XII 的K_i分别为 1203、99.7、9.4 和 27.7 nM。Carbonic anhydrase inhibitor 14 也能抑制CDK2，其IC₅₀为 20.3 μM。Carbonic anhydrase inhibitor 14 具有抗肿瘤活性。

生物活性

Carbonic anhydrase inhibitor14 (Compound 8b) is acarbonic anhydrase(CA)inhibitor withK_ivalues of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively.Carbonic anhydrase inhibitor14 can also inhibitCDK2with anIC₅₀of 20.3 μM.Carbonic anhydrase inhibitor14 shows antitumor activity^[1].

IC₅₀& Target

CDK2

20.3 μM (IC₅₀)

hCA XII

27.7 nM (Ki)

hCA IX

9.4 nM (Ki)

hCA II

99.7 nM (Ki)

hCA I

1203 nM (Ki)

分子量

395.44

Formula

C₁₈H₁₇N₇O₂S

CAS 号

2410402-75-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.