CDK2-IN-9

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CDK2-IN-9

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CDK2-IN-9 是一种有效的CDK2抑制剂，IC₅₀为 0.63 μM。CDK2-IN-9 显示出抗增殖活性。CDK2-IN-9 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S 和 G2/M 期。CDK2-IN-9 具有研究黑色素瘤的潜力。

生物活性

CDK2-IN-9 is a potentCDK2inhibitor with anIC₅₀of 0.63 μM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 inducesapoptosisand cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma^[1].

IC₅₀& Target^[1]

CDK2

0.63 μM (IC₅₀)

体外研究
(In Vitro)

CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC₅₀s of 3.03, 8.62, 62.52 μM for MDA-MB-435, SNB-75, WI-38 cells, respectively^[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase^[1].

Apoptosis Analysis^[1]

Cell Line:	MDA-MB-435, SNB-75 cells
Concentration:	3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
Incubation Time:	24 h
Result:	Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.

Cell Cycle Analysis^[1]

Cell Line:	MDA-MB-435, SNB-75 cells
Concentration:
Incubation Time:	24 h
Result:	Induced cell cycle arrest at S phase and G2/M.

分子量

441.89

Formula

C₂₁H₁₆ClN₃O₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.