ZLWT-37

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ZLWT-37

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

ZLWT-37 是一种有效的、具有口服活性的CDKs抑制剂，对CDK9和CDK2的IC₅₀分别为 0.002 μM 和 0.054 μM。ZLWT-37 诱导 HCT116 细胞凋亡 (apoptosis)，在 G2/M 期阻滞细胞周期。

生物活性

ZLWT-37 is a potent, orally activeCDKsinhibitor withIC₅₀values of 0.002 μM and 0.054 μM againstCDK9andCDK2, respectively. ZLWT-37 inducesapoptosisand arrests the cell cycle in the G2/M phase in HCT116 cells^[1].

IC₅₀& Target

CDK9

0.002 μM (IC₅₀)

CDK2

0.054 μM (IC₅₀)

体外研究
(In Vitro)

ZLWT-37 shows antiproliferative activity with a GI₅₀of 0.029 μM for HCT116^[1].

体内研究
(In Vivo)

ZLWT-37 (0-20 mg/kg; p.o.; once daily for 14 consecutive days) shows potential efficacy against the growth of implanted HCT116 cells in mice without obvious toxicity^[1].

分子量

464.00

Formula

C₂₆H₃₀ClN₅O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.