CDK8-IN-7

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CDK8-IN-7

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CAS NO:

2415156-30-6

CDK8-IN-7 (compound 12) 是一种有效的选择性细胞周期蛋白依赖性激酶 8 (CDK8)抑制剂，K_d为 3.5 nM。CDK8-IN-7 对 MOLM-13、OCI-AML3、MV4-11、NRK 和 H9c2 细胞具有细胞毒性，IC₅₀s 分别为 5.9、4.8、5.4、16.2、12.5-25 μM。CDK8-IN-7 具有研究AML-癌症的潜力。

生物活性

CDK8-IN-7 (compound 12) is a potent and selectivecyclin-dependent kinase8 (CDK8)inhibitor with anK_dof 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 5.9, 4.8, 5.4, 16.2, 12.5-25 μM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer^[1].

IC₅₀& Target^[1]

CDK8

3.5 nM (Kd)

分子量

428.65

Formula

C₃₀H₄₀N₂

CAS 号

2415156-30-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.