Chk2-IN-1 (compound 1) 是一种有效和选择性的checkpoint kinase 2 (Chk2)抑制剂，抑制Chk2和Chk1的IC50值分别为 13.5 nM 和 220.4 nM。Chk2-IN-1 可引发强烈的共济失调毛细血管扩张突变 (ATM) 依赖性 Chk2 介导的辐射防护作用。
| 生物活性 | Chk2-IN-1 (compound 1) is a potent and selective inhibitor ofcheckpoint kinase 2 (Chk2), withIC50s of 13.5 nM and 220.4 nM forChk2andChk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1]. |
| IC50& Target[1] | Chk2 13.5 nM (IC50) | Chk1 220.4 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
