Chk1-IN-5

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Chk1-IN-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2120398-39-0

Chk1-IN-5 是有效的检查点激酶 1 (Chk1) 抑制剂。Chk1-IN-5 抑制 Chk1 磷酸化，并在结肠癌异种移植模型中抑制肿瘤生长。

生物活性

Chk1-IN-5 is a potentcheckpoint kinase 1 (Chk1)inhibitor. Chk1-IN-5 inhibitsChk1phosphorylation and inhibits tumor growth in coloncancerxenograft model^[1].

IC₅₀& Target^[1]

Chk1

体外研究
(In Vitro)

Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells^[1].

体内研究
(In Vivo)

Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells^[1].
Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T_1/2=3.8 hours) and higher exposure (CL=2.3 L/hrokg; V_ss=6.4 L/kg; AUC=4531 ng/mloh)^[1].

Animal Model:	Baib/c nude mice with HT-29 colon cancer cells^[1]
Dosage:	40 mg/kg
Administration:	IV; twice a week for 21 days
Result:	Inhibited tumor growth.

Animal Model:	Male SD rats (280-350 g)^[1]
Dosage:	10 mg/kg
Administration:	Via tail vein intravenous injection
Result:	Displayed a longer half-life (T_1/2=3.8 hours) and higher exposure (CL=2.3 L/hrokg; V_ss=6.4 L/kg; AUC=4531 ng/mloh).

分子量

383.38

Formula

C₁₈H₁₈FN₇O₂

CAS 号

2120398-39-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.