Phenylacetic acid mustard

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

10477-72-2

Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator)，具有抗肿瘤活性。

生物活性

Phenylacetic acid mustard is the majormetaboliteof thecancerchemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity^[1].

IC₅₀& Target

IC50: metabolite of Chlorambucil^[1]

体内研究
(In Vivo)

Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED₁₅value of 8.0 mg/kg^[2].
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg^[2].

Animal Model:	Inbred male C3H/He mice^[1]
Dosage:	0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration:	Intraperitoneal injection; 15 days
Result:	Exhibited anti-tumor activities in vivo.

分子量

276.16

Formula

C₁₂H₁₅Cl₂NO₂

CAS 号

10477-72-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vivo:

1.
Phenylacetic acid mustard (PAAM) is dissolved in acidified ethanol (4.8 ml cone HC1 and 95% v/v ethyl alcohol in a volume of 100 ml) and diluted 1:9 with propylene glycol/K2HPO 4 buffer (20 g K2HPO4 plus 450 ml propylene glycol), final pH 7.4^[2].